Resumo

MAZOLA, Yuliet; RODRIGUEZ, Arielis  e  RODRIGUEZ, Rolando. Challenges for the design of effective vaccines or drugs against Cholera and Tuberculosis: Possible contributions from omics and bioinformatics. Biotecnol Apl [online]. 2009, vol.26, n.1, pp. 16-23. ISSN 1027-2852.

This manuscript shows the current situation of two re-emerging diseases: cholera and tuberculosis, which still constitute one of the major health problems in poor countries. In this regard, difficulties, challenges and perspectives for the development of new drugs and vaccines against these diseases are discussed. The possible contributions of structural biology, bioinformatics and ‘omics’ to obtain an effective treatment are also considered.

Palavras-chave : Tuberculosis; cholera; drug design; bioinformatics; vaccine; pathogenesis; proteomics; genomics.

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