Resumo

PEDROSO-SANTANA, Seidy. An updated approach to Multiple Sclerosis. Biotecnol Apl [online]. 2012, vol.29, n.1, pp. 1-6. ISSN 1027-2852.

Multiple Sclerosis is an inflammatory demyelinating disease of the Central Nervous System, chronic and with unknown pathogenesis. There is no cure for multiple sclerosis and the causes of the disease appear to be related with genetic and environmental components. The most accepted theory assumes a break of the immunoregulatory balance 'active T cells/regulatory T cells' and some evidences show the incidence of oxidative stress in the disease. The therapies that can reduce or stop the clinic symptoms and plaques formation cannot stop the illness progression, that's why the efforts for finding a new and efficient treatment still continue. The complementation of clinical information with molecular analysis could give more accuracy to a specific treatment. Better combinations of drugs and better therapies could be applied if the knowledge about the mechanisms of action of these drugs is improved.

Palavras-chave : multiple sclerosis; autoimmune; beta interferon; T cell; inflammation; central nervous system.

        · resumo em Espanhol     · texto em Inglês     · Inglês ( pdf )