Resumo

REMEDIOS BATISTA, Susel E et al. Ethiopathogenic Mechanisms in   the Systemic Sclerosis. ccm [online]. 2016, vol.20, n.1, pp. 122-136. ISSN 1560-4381.

A summary of the main ethiopathogenic factors that cause the clinical   expressiveness of the Systemic Sclerosis, still as soon as established, the genetic association, inheritance, environmental factors and inflammatory response, their relationship with endogenous infections behaving from a special way to other inflammatory rheumatic illnesses. The objective of this article was to describe the ethiopathogenic elements that distinguish this illness of the collagen. The ethiopathogenic mechanisms based on molecular abnormalities can be correct in the systemic sclerosis. Its heterogenic clinical spectrum responds to a different etiopathogeny in each individual, as well as to complex events that can happen in initial phases of the illness and not to a unique pathogenic.

Palavras-chave : systemic sclerosis; microkimerism; molecular mimetism; eskleros products; Smad proteins.

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