Resumo

MARTINEZ TELLEZ, Goitybell et al. Antineutrophil cytoplasmic antibodies determination for vasculitis diagnosis. Rev haban cienc méd [online]. 2013, vol.12, n.3, pp. 446-453. ISSN 1729-519X.

Introduction: antineutrophil cytoplasmic antibodies contribute to the diagnosis of systemic vasculitis. Objective: demonstrate the diagnostic value of Antineutrophil cytoplasmic antibodies assessing by indirect immunofluorescence doing its standardization and validation. Material and methods: standardization and validation of antineutrophil cytoplasmic antibodies determination by indirect immunofluorescence. The sample consisted of 20 patients with systemic vasculitis, 45 with rheumatic diseases and 24 healthy individuals. Results and Discussion: the sensitivity, specificity, and predictive values were adequate. Good method performance and good agreement was obtained with the reference tests. These antibodies were present in patients with vasculitis (54%), rheumatoid arthritis (19%) and systemic lupus erythematosus (37%). Conclusions: the developed method has a great diagnostic usefulness and can be applied in the study of systemic vasculitis, finding a good match between the patterns and antigenic specificities.

Palavras-chave : asculitis; standardization; validation; indirect immunofluorescence.

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