Resumo

RODRIGUEZ DUQUE, Raisa; EXPOSITO LARA, Alexander; FERIA DIAZ, Gisela Eduarda  e  MIGUEL SOCA, Pedro Enrique. Obesity and COVID-19: a dangerous dyad. Anales de la ACC [online]. 2022, vol.12, n.2  Epub 20-Jun-2022. ISSN 2304-0106.

A literature review was conducted on the links of obesity with adverse outcomes of SARS-CoV-2 infection. With the descriptors COVID-19, SARS-CoV-2, and obesity taken from Descriptors in Health Sciences (DeCS) at the review was conducted in: Google Scholar, PubMed Central, SciELO, and Infomed. Articles available in full text in Spanish and English were selected, with no restrictions as to the type of articles, from peer-reviewed journals and pages of recognized international organizations. The insulin resistance that accompanies obesity produces a chronic low-grade inflammatory state that leads to metabolic and hormonal disorders that increase the risk of severe disease by COVID-19, such as increased cellular entry of SARS-CoV-2 by increasing its cellular receptors, dysfunction of the immune response, altered hormone signaling, coagulopathy, and respiratory dysfunction.

Palavras-chave : obesity; insulin resistance; 2019 coronavirus disease; COVID-19; SARS-CoV-2; immunity; inflammation.

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