Resumo

NUNEZ-QUINTANA, Aramís; HONDAL-ALVAREZ, Norma I  e  AYLLON-VALDES, Lucía. Renal disorders in sickle cell disease. Rev Cubana Hematol Inmunol Hemoter [online]. 2011, vol.27, n.2, pp. 168-178. ISSN 1561-2996.

Sickle cell disease is associated with a wide range of renal disorders resulting from the falciformation of erythrocytes in vessels of the renal medulla, leading to ischemia, microinfarctions and tubular function abnormalities. Reversible glomerular functional renal self-regulation disorders (hyperfiltration) also occur, which may lead to irreversible anatomical changes with focal segmental glomerular sclerosis. These anomalies are expressed at an early stage as microalbuminuria and proteinuria, and at a later stage as nephrotic syndrome and chronic renal failure. Therapeutic measures such as the use of angiotensin-II converting enzyme inhibitors and angiotensin-II receptor blockers, associated or not with hydroxyurea, may either prevent or delay glomerular damage. The paper succinctly presents the physiopathology of renal damage in drepanocytosis and its treatment.

Palavras-chave : Sickle cell disease; hyperfiltration; microalbuminuria; nephrotic syndrome; angiotensin converting enzyme inhibitors.

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