Resumo

LAHERA-SANCHEZ, Tania  e  VILLEGAS-VALVERDE, Carlos A. From primary immunodeficiency to cancer. Rev Cubana Hematol Inmunol Hemoter [online]. 2011, vol.27, n.2, pp. 212-223. ISSN 1561-2996.

Rising survival rates among patients with primary immunodeficiency (PID) have increased the risk of developing cancer, which currently ranges between 4 and 25 %. A presentation is made of the PIDs associated with a high incidence of neoplasias: common variable immunodeficiency, selective IgA deficiency, ataxia-telangiectasia, Wiskott-Aldrich syndrome, immunodeficiency with thymoma (Good’s syndrome) and linfoproliferative disease linked to chromosome X (Duncan’s syndrome). The intervening pathogenic mechanisms are different for each disease and may include: inmmunosurveillance defects, increased chromosome susceptibility intrinsic to certain mutagens, infections caused by virus such as Epstein Barr, immunodysregulation of B cells due to defects in regulatory T cells, among others.

Palavras-chave : Primary immunodeficiency; cancer.

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