Resumo

MARSAN SUAREZ, Vianed; DEL VALLE PEREZ, Lázaro O  e  MACIAS ABRAHAM, Consuelo. Present aspects of organogenesis. Function and thymic involution. Rev Cubana Hematol Inmunol Hemoter [online]. 2013, vol.29, n.4, pp. 349-358. ISSN 0864-0289.

Thymus is a primary organ located in the antesuperior area of the torax. It is the principal place of differentiation and maduration of T cells. In this review present aspects of the embriology, histology and thymic function are detailed, as well as its role in the generation of different kinds of thymic cells; its differentiation to mature cells and of regulator T cells has a crucial role in tolerance induction. Moreover, thymic involution during of immunosenescence process is shown.

Palavras-chave : thymic organogenesis; T cells; positive selection; negative selection; thymic involution.

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