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Revista Cubana de Hematología, Inmunología y Hemoterapia
versão On-line ISSN 1561-2996
Resumo
PEREZ FUMERO, Yaxsunaris; GUERREIRO HERNANDEZ, Ana María e LEYVA RODRIGUEZ, Aymara. Autoimmune manifestations associated with coronavirus disease 2019. Rev Cubana Hematol Inmunol Hemoter [online]. 2022, vol.38, n.4 Epub 01-Dez-2022. ISSN 1561-2996.
Introduction:
Coronavirus disease 2019 (COVID-19), caused by a new coronavirus. Severe acute respiratory syndrome coronavirus 2 is having a devastating impact throughout the world. Its pathophysiology is the result of direct cytopathic effects of SARS-CoV-2 on respiratory epithelium, endothelium, other organ-specific cell types and the subsequent induction of a pro-inflammatory cytokine storm and dysregulated adaptive immunity, causing severe tissue damage.
Objective:
To describe autoimmune characteristics present during SARS-Cov-2 infection.
Methods:
A literature review on COVID-19 and autoimmune manifestations was carried out. The articles were selected from a search of the following websites: Pubmed, Medline, SciELO. An analysis and summary of the reviewed information was made.
Analysis and synthesis of information:
Viruses have been considered the main infectious agents that trigger autoimmune phenomena in genetically susceptible individuals. SARS-CoV-2 has already been linked to a long list of autoinflammatory and autoimmune conditions that can be induced by various mechanisms proposed to explain virus-induced autoimmunity. In this pathology, the most described, is molecular mimicry. COVID-19 shares similarities with autoimmune diseases in its clinical manifestations, pathophysiological mechanisms and therapeutic response, such powerful immune reactions participate in the pathogenesis of both entities.
Conclusions:
SARS-CoV-2 infection may represent the complex and interrelated link between infections and autoimmunity.
Palavras-chave : COVID-19; SARS-CoV-2; autoimmunity; autoantibodies.