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Revista Cubana de Investigaciones Biomédicas
versão On-line ISSN 1561-3011
Resumo
HERNANDEZ FERNANDEZ, Rolando A.. Molecular bases of von Hipperl Lindau's disease. Rev Cubana Invest Bioméd [online]. 2010, vol.29, n.2, pp. 262-273. ISSN 1561-3011.
The von Hippel Lindau's disease is uncommon genetic entity characterized by a predisposition to cancer, specially the retina angiomas, hemangioblastomas of central nervous system and the clear cells renal carcinoma. Gene products have a typical action mechanism since it is related to organism adaptation processes to hypoxia. In present paper an updated panorama of this disease emphasizing in molecular processes.
Palavras-chave : von Hippel Lindau; hypoxia; angiomas; pheochromocytomas; clear cells renal carcinoma; ubiquitin ligase.