Resumo

LOPATEGUI CABEZAS, Ileana  e  HERRERA BATISTA, Aleida. Papel crucial de la mitocondria en la muerte celular programada. Rev Cubana Invest Bioméd [online]. 2010, vol.29, n.2, pp. 294-301. ISSN 1561-3011.

The apoptosis has been related to significant processes including the embryo development and the organogenesis, the maintenance of the appropriate number of cells and the elimination of those damaged, aged or potentially dangers. A bibliographic review was made on the key role playing the mitochondria in the carrying out, amplification and regulation of apoptosis, the main implicated molecules, the morphological and biochemical alterations suffered by this organelle during this event, among them the release or proteins from the inter-membranous space, each with pro-apoptosis key functions and different fates, the opening of the permeability transition pore, the alterations of homeostasis of Ca2+, and the formation of apoptosome in cytosol. The knowledge of all participants of apoptosis process approach us to understanding of physiological and pathological processes accounting for apoptosis increase of inhibition.

Palavras-chave : Apoptosis; mitochondria; mitochondrial pore; Apoptosome.