Resumo

VIZOSO PARRA, Ángel et al. Derivados antraquinónicos del Aloe vera L: Tamizaje genotóxico. Rev Cubana Plant Med [online]. 2000, vol.5, n.2, pp. 46-50. ISSN 1028-4796.

Results obtained are based on sifting through of possible mutagenic effect of and extract from anthraquinone derivatives of Aloe vera L. In three short-term trial systems, two of them were in vitro using Ames´ trial and mitotic segregation test in D-30 Aspergillus nidulans fungus, and another in vitro too, using micronuclei induction trial in bone marrow of mouse. In Ames´ trial concentrations up to 5 mg/plate for TA-1535, TA-1537, TA-98 and TA-100 strains, were assessed. In mitotic segregation, concentrations up to 0,730 mg of total solids/mL of complete culture medium. For micronuclei induction trial, a dose rank of 500, 1 000, and 2 000 mg/kg of body weight of rodent was analysed. Results obtained show that extract anthraquinone derivatives of Aloe vera L. was genotoxic in Ames´ trial in TA-1537 stran with metabolic activation hasn´t neither the cytotoxic nor genotoxic effect in mytotic segregation trial. In in vitro test, there wasn´t a significant genotoxic response in frequency of micronuclei in polychromatic red cells and medullary damage.

Palavras-chave : ALOE; ANTHRAQUINONES; ASPERGILLUS NIDULANS; BONE MARROW; MUTAGENICITY TESTS; MICRONUCLEUS TESTS; MICE;; IN VITRO.

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