Resumo

BERMUDEZ GARCELL, Alejandro Jesús et al. Cancer Biology. ccm [online]. 2019, vol.23, n.4, pp. 1394-1416.  Epub 01-Dez-2019. ISSN 1560-4381.

Cancer is a health problem with a significant economic and human impact. Cancer mortality has been increasing constantly over the last 25 years all over the world. Its incidence and mortality go up with age, therefore our population ageing will boost financial costs related to diagnosis, treatment and rehabilitation. Cancer is caused by specific gene somatic mutations; it is considered that between 5 and 10 sequential mutations are necessary to produce a malignant cell. Knowledge of cancer molecular mechanisms allows the implementation of specific therapeutic procedures, like some lifestyle changes that could prevent the disease, as well as the development of new medications.

Palavras-chave : molecular mechanisms; oncogenes; proto-oncogenes; cancer suppressor genes.

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