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versão On-line ISSN 1560-4381
Resumo
FIALLO COBOS, Rodrigo; GOMEZ LEYVA, Berlis e DIAZ ARMAS, María Teresa. Heberprot-P®: therapeutic effectiveness in diabetic foot ulcer patients at General Teaching Hospital of Chimborazo, Ecuador. ccm [online]. 2020, vol.24, n.1, pp. 100-116. Epub 01-Mar-2020. ISSN 1560-4381.
Introduction:
diabetic foot ulcer is a health problem which requires effective treatment to decrease the rate of amputations.
Objective:
to evaluate the therapeutic effectiveness of Heberprot-P® (recombinant human epidermal growth factor), applied to diabetic foot ulcer patients.
Methods:
non-randomized, uncontrolled trial in 51 diabetic foot patients treated with Heberprot-P® at General Teaching Hospital of Chimborazo, Riobamba, Ecuador, during the period from January to December 2013. The variables analyzed were: age, sex, type of diabetes, place of origin, clinical classification of disease, injury classification, number of infiltrations carried out, treatment time, response to it and adverse events.
Results:
the most predisposed to diabetic foot ulcers was the 60-70 age group and the female. 58.8% of the patients presented neuroinfectious diabetic foot. According to Wagner classification, in Grade II injury, the most frequent, after 24 infiltrations of Herberprot P®, the response to the treatment observed was total healing in 70.5% and partial in 27.5%, being satisfactory in 98% of the patients within a period of 50 days. The main adverse effect found was chills.
Conclusions:
the effectiveness of Heberprot-P® in the treatment of diabetic foot ulcer patients is confirmed, in addition to being an effective and safe drug for application.
Palavras-chave : diabetes mellitus; diabetic foot ulcer; treatment; epidermal growth factor; adverse events.