Resumo

ALVAREZ ALVAREZ, Aimée et al. Frequency of Gly105Asp polymorphism of the IRS-2 gene in a group of the Cuban population: its relation to Type 2 diabetes mellitus and the overweight. Rev Cubana Endocrinol [online]. 2008, vol.19, n.3, pp. 0-0. ISSN 1561-2953.

INTRODUCTION: Type 2 diabetes mellitus is one of the more hard-bitting pandemic at world level. Genetic susceptibility is an important risk factor of it, as well as the effect of environmental factors, and lifestyles. OBJETIVE: to explore role of Gly1057Asp polymorphism of IRS-2 gene in genetic oversensitivity for Type 2 diabetes mellitus. METHODS: frequency of Gly1057Asp polymorphism of IRS-2 gene in was studied in 499 Cuban citizens, with IMC³22 and <30, aged from 40 to 70, of them, 272 (54,5 %) were diabetic people and 277 (45,5 %) were non-diabetic. For comparison of frequency of this polymorphism in both groups, we used ²Chi test (p<0,05), and to quantify associations, we used crossed-products ratio. RESULTS: frequency of Asp1057 allele of Gly1057Asp polymorphism of IRS-2 gene was of 49,8 % in diabetic patient group, and of 58,8 % in the group on non-diabetic one (p<0,05), suggesting that this allele confers protection against diabetes. However, this pattern of frequency distribution changes in persons overweighed, in which presence of Asp1057 allele becomes associated with hyperinsulinism. In subjects with family backgrounds of Type 2 diabetes mellitus, protection of Asp1057 allele is not expressed. CONCLUSION: in group of study Cuban population, Asp1057 allele of IRS-2 gene confers protection against Type 2 diabetes mellitus. Overweight and family backgrounds modify this protective action

Palavras-chave : mellitus; genetic susceptibility; IRS-2.