Resumo

CABRERA SUAREZ, Hirán R. et al. Toxicity studies and an antitumoral evaluation of the alcoholic extracts for P. tithymaloides. Rev haban cienc méd [online]. 2008, vol.7, n.3, pp. 0-0. ISSN 1729-519X.

With the aim to determine possible effect against carcinomas, in accordance with reports from traditional medicine for P. tithymaloides, toxicity studies and an antitumoral evaluation of the alcoholic extracts from leaves (IRH) and stalks (IRT), on Ehrlich ascistic tumor (TAE) were carried out. NMRI mices were used (3 groups of 10 animals in each experiment); Animals were given a dose of 2000 mg/Kg from each extract in toxicity studies. For antitumoral evaluations, experimimental tumoral cell (TAE) were given to the mice initially and then were treated with IRT and IRH at concentrations of 25 mg /Kg 50 mg/ Kg and 100 mg/ Kg p.o. Positive control animals received 5 fluoracile (20 mg/ Kg.) i.p. and negative controls were treated with saline solution of sodium chloride (0.9% NaCl) p.o. Toxicity signs were evaluated via an Irwin test. Survival increase percentages (AS) were also determined. Results were analyzed by the Kapplan- Meler statical method and the survival curves were compared for each group by the Long Rank test (p<0.05) . Result did not confirm presences of antitumoral activity in any of the extracts evaluated to experimental model carried out. For the 50 mg / Kg dose of IRH a slight increase of the animals’ lifespan as compared to the rest of the administered doses. There was a lower survival with 100mg/Kg of IRH

Palavras-chave : Pharmacology; Cáncer; Pedilanthus tithymaloides (L.) Poit; Alcohol extracts of Pedilanthus tithymaloides (L.) Poit.

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