Resumo

MARQUETTI HERNANDEZ, Anay  e  GESSNER, Reinhard. The cadherins in the histopathology diagnosis and prognosis of renal cell carcinoma. Rev haban cienc méd [online]. 2011, vol.10, n.1, pp. 45-53. ISSN 1729-519X.

Renal cell carcinoma is the most common adult renal cancer. Five main histological types are described, that in general display characteristic light microscopic features that lead to a correct diagnosis. However, the morphologic overlap between tumors and the histologic heterogeneity within a single tumor continue to create problems in the classification. Some immunohistochemical markers are used in the differential diagnosis of these carcinomas, but they have limitations. In the present work, a review of several studies was made, in which alterations in expression of some cadherins in renal tissue and cell lines with renal cell carcinoma were identified. These alterations were associated with different stages of tumor development and progression, and used to predict the neoplastic behaviour. To increase our knowledge in this field, will contribute to find more specific markers for the diagnosis and prognosis of these tumors.

Palavras-chave : renal cell carcinoma; diagnosis; prognosis; cadherins; immunohistochemical markers..

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