Resumo

HERNANDEZ FERNANDEZ, Rolando A. Ubiquitin-proteasome pathway to built or to destroy? that is the question. Rev haban cienc méd [online]. 2013, vol.12, n.1, pp. 22-34. ISSN 1729-519X.

Introduction: the generation of new cells is an extremely complex process. To become this process unidirectional and irreversible cells destroy proteins which actions are oppose to the transition from one phase to the next one. Objective: to show that protein destruction is essential for cell reproduction. Material and Methods: more than 500 papers published during the last five years in national and international journals were analyzed. These articles are available in HINARI, PubMed, and Perii databases and were localized through infomed. Development: first, the ubiquitin-proteasome pathway is presented. Next, the contribution of the complexes SCF an anaphase promoting complex to the progression of the cell cycle is analysed. These complexes act consecutively and coordinately and their actions determine de progression of the cell´s life. Conclusions: the selective destroy of specific proteins by mean of ubiquitin-proteasome pathway, allow new cells formation, and ensure the continuity of life

Palavras-chave : ubiquitin; ubiquitin-ligase; SCF complex; APC complex; cell cycle.

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