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Revista Habanera de Ciencias Médicas
versão On-line ISSN 1729-519X
Resumo
GONZALEZ ESPINOSA, Claudia et al. Value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography ın the diagnosis of carcinoma of unknown primary origin. Rev haban cienc méd [online]. 2019, vol.18, n.6, pp. 873-885. Epub 03-Dez-2019. ISSN 1729-519X.
Introduction:
The incidence of carcinoma of unknown primary origin in oncologic patients is from 0,5 % to 7 % at the time of diagnosis with an overall 3-year and 5-year survival of 11 % and 6%, respectively.
Objective:
To assess the effectiveness of 18 F-FDG-PET/CT (18F-fluorodeoxyglucose posıtron emıssıon tomography) in the diagnosis of carcinoma of unknown primary origin (CUP).
Material and Methods:
F-FDG-PET/CT studies were conducted in patients with CUP in the search for primary tumor with negative previous conventional studies carried out from November, 2017 to June 2018. The final diagnosis was established by histological confirmation and/or clinical/radiological follow-up during 8 months.
Results:
A total of 44 patients were studied. There were evidences of suggestive CUP in 19 patients; 9 of them were histologically confirmed as true-positive and only 1 was a false-positive. Of the 23 patients with negative F-FDG-PET/CT studies for primary tumor, all of them continued with the diagnosis of CUP in spite of multiples diagnostic tests. Conclusions: The FDG-PET/CT technique allowed to identify 45,2 % of the primary tumors in this study, which demonstrates that it is very useful tool for the diagnosis of metastases of unknown origin. It is considered that F-FDG-PET/CT studies should be included earlier in the diagnostic algorithms in Cuba, which will allow to indicate subsequent complementary tests.
Palavras-chave : Tumor of unknown origin; CUP; PET/CT; F-FDG-PET/CT; metastases from unknown primary tumor.