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Revista Habanera de Ciencias Médicas
versão On-line ISSN 1729-519X
Resumo
LA ROSA HERNANDEZ, Deyanira e CASTELLANOS FERNANDEZ, Marlen Ivon. Advances in the immunopathogenesis of autoimmune hepatitis. Rev haban cienc méd [online]. 2022, vol.21, n.2 Epub 10-Maio-2022. ISSN 1729-519X.
Introduction:
Immunopathogenic mechanisms are not fully clarified in autoimmune hepatitis; there are many investigations in this field with a view to enriching knowledge and expanding therapeutic options.
Objective:
To synthesize the most recent knowledge about the immunopathogenesis of this disease.
Material and Methods:
An exhaustive search of the bibliography available in SciELO, ScienceDirect, Google Scholar and PubMed was carried out, including review articles, experimental, clinical, cohort and meta-analysis studies.
Development:
The main mechanisms of central and peripheral tolerance are explained, as well as the role of lymphoid subpopulations, cytokines and the microenvironment in the pathogenesis of the disease.
Conclusions:
Advances in the knowledge of the immunopathogenesis of autoimmune hepatitis allow a better understanding of this disease and are the referents in the design of future treatment strategies.
Palavras-chave : autoimmune hepatitis; liver tolerance; antigen presenting cells; lymphoid subpopulations; autoantibodies; gut microbiota.