Resumo

CAMPO FARNANDEZ, Mercedes; PERDOMO LOPEZ, Iliana; IRAIZOZ COLARTE, Antonio  e  HECTOR RODRIGUEZ, Maité. Diseño tecnológico de tabletas de Desipramina de liberación controlada. Rev Cubana Farm [online]. 2001, vol.35, n.3, pp. 165-170. ISSN 1561-2988.

A preliminary study was conducted aimed at obtaining controlled-release desipramine hydrochloride tablets (75 mg). There are no antecedents about their manufacture in world literature. 5 technological variants of formulation were designed and very encouraging results were obtained on using Cuban technical dextran and hidroxypropylmethylcellulose (HPMC) as retarding agents in the mass and agglutinate it with a chloroform solution of cetyl alcohol, with which tablets with excellent physico-mechanical and technological properties were obtained. A satisfactory dissolution kinetics with a t_{100 %} of approximately 14 hours of in vitro assay was also attained.

Palavras-chave : TECHNOLOGY, PHARMACEUTICAL; DESIPRAMINE [pharmacology]; DESIPRAMINE [pharmacokinetics]; DRUG COMPOUNDING [methos]; DRUG INDUSTRY; CHEMISTRY, PHARMACEUTICAL [methods]; TABLETS.

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