Resumo

RODRIGUEZ PERON, José Miguel  e  MENENDEZ LOPEZ, José Rogelio. Administración de cartílago de tiburón a pacientes con función inmunológica comprometida por radiaciones ionizantes. Rev Cub Med Mil [online]. 2000, vol.29, n.3, pp. 185-191. ISSN 1561-3046.

A simple open non placebo-controlled randomized prospective study which included 38 patients seen in the Oncological Outpatient Service of "?Dr Luis Díaz Soto" Higher Institute of Military Medicine and and unequivocally diagnosed (clinically and histologically) with epithelial solid neoplasia. After beginning specific oncologic radiotherapy and verifying that initial absolute granulocytes and/or lymphocytes counts were below 30% of the normal values in patients chosen for the study, they were assigned to 4 groups of treatment with pure shark cartilage powder (SCP) for 12 weeks. Group 1(n=15) was treated for 3 months with an oral dose of 6g per day of SCP; group 2(n= 8) and 3(n=8) were given a daily dose of 12 g and 18 g respectively during the same period of time whereas group 4(n= 7) was not treated (control group). The evaluation of the immunologic performance at the beginning and at the end of the treatment using circulating immunocomplexes (CIC) and active rosette assay and spontaneous rosette assay were made in all the groups.In comparison with the control group, the administration of any of the dose prescriptions of PSCP brought about significant quantitative values in immune parameters. It was observed that CIC titers increased 2.7 times, AR values by 9% and ER by 15% in patients treated with 6 g of SCP a day. CIC titers increased 4 times, AR values by 12% and ER values by 29% in the group treated with 12g. Dose of 18g/d of PSCP was associated with intolerance.

Palavras-chave : TISSUE EXTRACTS [therapeutic use;]; CARTILAGE; SHARK; RADIATION INJURIES [drug therapy]; IMMUNOCOMPROMISED HOST; RADIATION INJURIES [immunology].

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