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Revista Cubana de Medicina Militar
versão On-line ISSN 1561-3046
Resumo
PERDOMO REBAZA, María Teresa et al. Risk of preeclampsia and Vitamin C and E supplementation: a systematic review and meta-analysis. Rev Cub Med Mil [online]. 2022, vol.51, n.3 Epub 01-Set-2022. ISSN 1561-3046.
Introduction:
It has been suggested that preeclampsia can be prevented by vitamin E and C intake, given the pathophysiological mechanism of this disease.
Objective:
To determine the joint efficacy of vitamin C and E in the prevention of preeclampsia.
Methods:
Systematic review of randomized clinical trials. A search of pubmed/medline, SCOPUS, Web of Science, Cochrane Library, EMBASE, and Clinical Trials databases was performed. The risk of bias of the randomized clinical trials was assessed using the Cochrane tool version 2. A random-effects meta-analysis was performed and relative risks were calculated, with corresponding 95 % confidence intervals.
Results:
Seven studies were included (n= 1 475). No statistically significant association of treatment with vitamin C and E supplementation was found with respect to preeclampsia (relative risks: 1.03; 95 % CI 0.78-1.26).
Conclusions:
Dual vitamin C and E supplementation does not prevent preeclampsia in pregnant women at risk for the disease.
Palavras-chave : pre-Eclampsia; vitamin C; vitamin E; disease prevention.