Introduction:

It has been suggested that preeclampsia can be prevented by vitamin E and C intake, given the pathophysiological mechanism of this disease.

Objective:

To determine the joint efficacy of vitamin C and E in the prevention of preeclampsia.

Methods:

Systematic review of randomized clinical trials. A search of pubmed/medline, SCOPUS, Web of Science, Cochrane Library, EMBASE, and Clinical Trials databases was performed. The risk of bias of the randomized clinical trials was assessed using the Cochrane tool version 2. A random-effects meta-analysis was performed and relative risks were calculated, with corresponding 95 % confidence intervals.

Results:

Seven studies were included (n= 1 475). No statistically significant association of treatment with vitamin C and E supplementation was found with respect to preeclampsia (relative risks: 1.03; 95 % CI 0.78-1.26).

Conclusions:

Dual vitamin C and E supplementation does not prevent preeclampsia in pregnant women at risk for the disease.

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