SciELO - Scientific Electronic Library Online

 
vol.36 número1Aspectos genéticos moleculares del síndrome de trombocitopenia con ausencia de radios índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Artigo

Indicadores

  • Não possue artigos citadosCitado por SciELO

Links relacionados

  • Não possue artigos similaresSimilares em SciELO

Compartilhar


Revista Cubana de Hematología, Inmunología y Hemoterapia

versão On-line ISSN 1561-2996

Resumo

TRIANA MARRERO, Yenisey  e  MARSAN SUAREZ, Vianed. Applications of flow cytometry in the study of chronic lymphoproliferative syndromes. Rev Cubana Hematol Inmunol Hemoter [online]. 2020, vol.36, n.1  Epub 01-Jul-2020. ISSN 1561-2996.

Introduction:

Flow cytometry is an advanced, objective and highly sensitive technique that allows simultaneous quantification and analysis of multiple cellular parameters. It is widely used in the study of malignant hemopathies. In recent years, it has proved very useful in the identification and immunophenotypic characterization of chronic lymphoproliferative syndromes. These conditions belong to a heterogeneous group of diseases characterized by monoclonal expansion of mature lymphoid cells.

Objectives:

To analyze the general aspects of flow cytometry application to the study and immunophenotypic classification of chronic lymphoproliferative syndromes.

Methods:

A bibliographic-documentary research about the topic was carried out. We consulted the SciELO and Pubmed databases.

Information analysis and synthesis:

The technical aspects of the flow cytometry are described, from obtaining and processing the samples to the cytometer’s generating the report; as well as the technique’s application to the immunophenotypic characterization of chronic lymphoproliferative syndromes. Multiparametric flow cytometry has become one of the diagnostic methods for this syndrome. One of the main objectives of the immunophenotypic study by flow cytometry is to rule out whether this population of B cells is clonal or not.

Conclusions:

Flow cytometry allows the analysis, interpretation and immunophenotypic classification of chronic lymphoproliferative syndromes. It is a useful tool that supports the diagnosis and monitoring of these patients.

Palavras-chave : flow cytometry; immunophenotype; chronic lymphoproliferative syndrome.

        · resumo em Espanhol     · texto em Espanhol     · Espanhol ( pdf )