Resumo

GARZON-ALVARADO, Diego Alexander; RAMIREZ MARTINEZ, Angélica María  e  SILVA, Octavio. Description of cancer metastasis in bone tissue through a mathematical model. Rev Cubana Invest Bioméd [online]. 2010, vol.29, n.1, pp. 0-0. ISSN 1561-3011.

Metastasis is the fast proliferation of cancer cells, secondary tumor in a specific site, that in general lead to death. This process occur in anatomical sites providing the necessary environment of vascularization, oxygen and food allowing to camouflage its action for triggering the fast growing of cancer. Prostrate and breast cancer use by example, the bone marrow for its proliferation. Thus, the bone gives support for the adjustment cells to environment; mimic the genetic and molecular behavior of bone cells. In present paper the cancer metastasis process is simulated with bone marrow activation. Authors propose a mathematical model involving the molecular activation by the bone tissue cells, needed for cancer proliferation. In this order of ideas two ways of secondary tumor growth is simulated according the type of metastasis: The osteosclerosis and osteolysis.

Palavras-chave : Cancer; metastasis; molecular mechanisms; bone marrow.

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