Resumo

CORONA LISBOA, José Luis. Genetic causes related to anomalies in sex differentiation in mammals. Rev Cubana Invest Bioméd [online]. 2015, vol.34, n.4, pp. 378-383. ISSN 1561-3011.

Determination of genetic sex takes place at the time of fecundation whereas differentiation of gonadal and genital sexes occurs during critical periods of embrionary life. The factors that modify the mechanisms of sex differentiation are varied and their anatomical and pathological, genetic and molecular study have attracted many researchers interested in this topic. The objective of the present article was to describe the genetic anomalies related to the development in sexual morphophysiology of mammals, starting from a deductive approach on the basis of reported research works on this topic. According to the information, it was concluded that anomalies of the chromosomal, gonadal and genital sex respond to a series of genetic alterations that involve a set of enzymatic cascades affecting the normal course of the sexual morphophysiological development of the animal.

Palavras-chave : anomaly; hermaphroditism; intersex; gonads; genitalia.

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