Introduction:

Knowledge about the effects of electrochemotherapy on organisms may be important for the treatment of various diseases.

Objective:

Evaluate the effects of low-intensity direct electric current on healthy mice.

Methods:

Eighty healthy C57BL/6/Cenp mice (40 male and 40 female) were randomly distributed in eight experimental groups (four control and four treated). Direct electric current (10 mA during 5 min) or constant voltage (10 V during 5 min) was applied to the mice. Clinical, macroscopic and microscopic observation was performed, and measurements were taken of hematological and biochemical parameters of the blood.

Results:

Reversible changes were induced in hematological, biochemical and histological parameters of the blood of male and female C57BL/6/Cenp mice when 10 mA or 10 V and various electrode arrays were used. These changes were less noticeable in the constant voltage mode.

Conclusions:

The alterations induced by low-intensity direct electric current in healthy C57BL/6/Cenp mice are reversible. The systemic inflammatory process is dominated by the lymphocytes.

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