Resumo

TORRES TELLEZ, Kirene; RUIZ HUNT, Zaddys  e  QUESADA LEYVA, Lidyce. Mycobacterium tuberculosis vaccine candidates: an update on the topic. AMC [online]. 2017, vol.21, n.1, pp. 876-891. ISSN 1025-0255.

Background: The tuberculosis constitutes a serious sanitary problem. The vaccination is a powerful method to prevent the infections. The effectiveness protector of the current vaccine against the tuberculosis, to counteract the lung forms of this illness and its reactivation, is variable or not very efficient, that which imposes the urgent search of new alternative prophylaxes against this illness. The advance in the obtaining of bovine and of new more effective drugs, it depends in great measure of the knowledge of the characteristics of the microorganism as well as the answer of the immune system in the pathogen agent's function. Objectives: to carry out an up-to-date revision on the Candidates vaccinates them against Mycobacterium tuberculosis. Methods: you real it hoisted a bibliographical revision of a total of 60 published articles, of them 40 articles corresponding to the last decade were chosen to conform the investigation. The relating more used topics were shown to pathogen agent Mycobacterium tuberculosis candidate vacunal and the mechanisms of action on the immune system. It was deepened on the types of vaccine and the therapeutic potentialities, specific for the M. tuberculosis, besides, to evaluate the immunologic implication with relationship to the candidate vacunal. Conclusions: The simulation of the infection and the immune events that happen him in the establish ment of the natural immunity, without causing the illness are essential conditions of a classic vaccine.

Palavras-chave : MYCOBACTERIUM TUBERCULOSIS; TUBERCULOSIS VACCINES; NOXAE; IMMUNITY, ACTIVE; REVIEW LITERATURE AS TOPIC.

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