Resumo

LANDYS, Mario; FIGUEROA, Juan Miguel; LARA, Ana  e  PERDOMO, Vicente. Interaction of the whole-cell pertussis component with the the tetanus antigens, type b Haemophilus influenzae and hepatitis B in potency assays for combined vaccines. Vaccimonitor [online]. 2008, vol.17, n.1, pp. 7-15. ISSN 1025-0298.

Combined vaccines have a higher level of acceptance in the population because fewer immunisations are required for protection against infectious diseases. Nevertheless, new challenges have appeared due to the report of some interference among the antigens included in such vaccines. The aim of this paper was to evaluate whole-cell Pertussis (wP) interference in potency tests with other antigens like tetanus, Haemophilus influenzae type b (Hib) and hepatitis B. For that purpose, we evaluated combined vaccines and compared them with the respective monovalent vaccines. Likewise, we prepared experimental formulations with different antigen combinations to evaluate the extent and nature of the interference caused by wP. We obtained a significant increase of the tetanus and Hib biological activities when both antigens are combined with wP, although it depended on the animal model and the experimental design used. On the other hand, wP decreased both the in vivo and in vitro potency of HB in a non-significant way.

Palavras-chave : Whole-cell pertussis; interference; hepatitis B; tetanus toxoid; hepatitis B and Hib antigen potency.

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