Resumo

ISEA, Raúl. Prediction of consensus linear B-cell epitopes in Plasmodium falciparum 3D7 . Vaccimonitor [online]. 2013, vol.22, n.1, pp. 43-46. ISSN 1025-028X.

Today it is estimated that half world population can be infected by malaria and there is not an available vaccine, however, there is hope with vaccine RTS,S/AS02. For this reason, we must continue to develop computer methodologies and strategies that will allow the rational design of potentially effective vaccines. We propose a new computational approach to predict linear B-cell epitopes from the whole genome sequencing of Plasmodium falciparum 3D7, obtained from IEDB database. Those that were repeated were discarded and were grouped into blocks according to the obtained results by Redundancy and Nomad programs. Subsequently, the possible antigenic character was predicted using the programs BepiPred, BcePred and BCPred. Three potentially antigenic sequences out of the 45 predicted were obtained with this methodology, but it is not possible to say which one the most antigenic without experimental evidence.

Palavras-chave : B-cell epitope; malaria vaccine; ExPASy; Plasmodium falciparum.

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