SciELO - Scientific Electronic Library Online

 
vol.24 número3Obtención de anticuerpos policlonales IgY antiparvovirus canino y evaluación en un sistema de aglutinación con látexCaracterización molecular de un aislamiento cubano de parvovirus canino índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Artigo

Indicadores

  • Não possue artigos citadosCitado por SciELO

Links relacionados

  • Não possue artigos similaresSimilares em SciELO

Compartilhar


Vaccimonitor

versão On-line ISSN 1025-0298

Resumo

OROPESA-FERNANDEZ, Suset et al. Antigenic and molecular characterization of influenza A (H3N2) virus strains circulating in Cuba and their relation with vaccine strains (1995-98). Vaccimonitor [online]. 2015, vol.24, n.3, pp. 0-0. ISSN 1025-0298.

The continuous antigenic changes in the influenza viruses occurring primarily on the envelope glycoproteins (hemagglutinin and neuraminidase) are due to specific mutations and to those promoted by the positive selection of the immune system originating the yearly epidemics and the rearrangements of genomic segments, cause of the feared pandemics. The attempts to control the influenza by means of vaccination have so far a limited success and they are obstructed by these changes. The acute respiratory infections are the first cause of medical assistance among the infectious diseases in Cuba, a subtropical country and the fourth cause of death associated with pneumonia. The surveillance for the influenza in this country is monitored by the National Center of Influenza from "Pedro Kourí" Tropical Medicine Institute. The present paper has the objective to characterize 21 strains of influenza isolated from 1995 to 1998 and to know the antigenic and genomic similarity with those of the international circulation included in anti-flu of the same period. The antigenic and genomic characterization was carried out by means of the inhibition techniques of hemagglutination, immunoperoxidase, and a reverse system of transcription-polymerase chain reaction, respectively. Using these three techniques 100% of the isolations were of the type A and the subtype H3N2. It allowed to classify them as similar to the circulating strains of international circulation recommended in the composition of the flu vaccine corresponding to those season.

Palavras-chave : influenza; influenza vaccines; antigenic characterization; molecular characterization.

        · resumo em Espanhol     · texto em Espanhol     · Espanhol ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License