Resumo

VIZOSO PARRA, Ángel et al. Extracto hidroalcohólico de cera de caña no induce daño genético. Rev Cubana Plant Med [online]. 2002, vol.7, n.1, pp. 18-22. ISSN 1028-4796.

The utilization of medicinal plants and their derivatives in traditional medicine finds its natural expression and its further development in primary health care. Cuba has taken advantage of its rich flora and of its vast tradition in the use of phytodrugs. The sugar cane wax is among these alternative products. It is obtained as a by-product in the sugar manufacture process and it has well-known pharmacological properties (antiinflammatory, healing, etc.). The genotoxic studies were conducted by using 3 short-term test systems, 2 in vitro and 1 in vivo. The tests of Salmonella/Microsomas (Ames) and mitotic segregation (Aspergillus nidulans D-30) were used for in vitro assays at a maximum concentration of the product of 5 mg/plate and 1.00 mg/mL, respectively. In the in vivo test of micronucleus induction in mouse bone marrow, doses of up to 2 000 mg/kg of body weight were used. The results showed that the hydroalcoholic extract of sugar cane wax has no mutagenic effect on any of the tests used.

Palavras-chave : PLANTS, MEDICINAL [toxicity]; PLANT EXTRACTS [toxicity]; MUTAGENECITY TESTS, SALMONELLA; ASPERGILLUS NIDULANS; MICRONUCLEUS TESTS; RATS, WISTAR.

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