Resumo

BLANCO HERNANDEZ, Neylim; RAMOS RUIZ, Alberto  e  VIZOSO PARRA, Ángel. Toxic and genotoxic evaluation of the fluid extract from Ocimum gratissimum L. . Rev Cubana Plant Med [online]. 2006, vol.11, n.1, pp. 0-0. ISSN 1028-4796.

The acute toxicity and the genotoxic activity of the fluid extract of leaves of Ocimum gratissisum L. were evaluated by two short-term assay systems, one in vitro with the strain D-30 from Aspergillus nidulans, and another in vivo, the micronucleus test in mouse bone marrow. The acute toxicity of the extract was proved by the mortality observed that rose to 50 % in the 3g/kg dose, which was dose dependant. It was found a little accentuated genotoxic response of the fluid extract of O. gratissimum 30 %. The results allowed to conclude that this extract showed acute toxic effects and histologic signs of hepatotoxicity and nephrotoxicity. It was not genotoxic neither for the strain D-30 from Aspergillus nidulans in the mitotic segregation test, nor in the micronucleus test in mouse bone marrow.

Palavras-chave : Ocimum gratissimum L; Aspergillus nidulans ; micronuclei test; acute toxicity; genotoxicity.

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