Resumo

CABRERA RODE, Eduardo et al. Helicobacter pylori and islet cells antibodies in diabetes mellitus. Rev Cubana Endocrinol [online]. 2002, vol.13, n.1, pp. 0-0. ISSN 1561-2953.

66 ICA-positive patients were studied: 21 type 1 diabetics, 24 diabetics initially classified as type 2 and 21 first-degree relatives of type 1 diabetics. They were compared with 101 ICA-negative patients: 20 type 2 diabetics, 20 first-degree relatives, 21 children and 40 non-diabetic adult controls to analyze if the immunolgical response to H. pylori is associated with islet cell antibodies (ICA). The ICA were determined by the indirect immunofluorescence method with prolongued incubation and the levels of antibodies (IgG) versus H. pylori (HP) by an ELISA using a commercial kit. It was observed a frequency of antibodies (IgG) versus H. pylori of 38.0 % (25/66) in ICA-positive patients and of 39.6 % (40/101) in ICA-negative patients. No correlation was found between the presence of antibodies (IgG) versus H.pylori and the ICA in the studied groups. There were no differences as regards the presence of IgG anitbodies versus H. pylori between diabetes mellitus and the controls (47.7 % [31/65] vs. 40.9 % [ 25/61]). It was observed a high percentage of antibodies (IgG) vs. H. pylori in type 1 diabetics (33 %, 7/21) in relation to the controls (14 %, 3/21), but with no significant differences. The frequence of antibodies vs. Helicobacter in adult controls is higher than in children (55 %, 22/40 vs. 3/21, p=0.0025). The frequency of antibodies vs. H. pylori is much more elevated in the adult controls may be because of the greater possibility of exposure to reinfections. In spite of these results, we do not exclude the idea that the infection due to H. pylori is related to type I diabetes, since some studies suggest that IgG versus H. pylori does not persist for a long time.

Palavras-chave : HELICOBACTER PYLORI [immunology]; DIABETES MELLITUS [complications]; DIABETES MELLITUS, INSULIN-DEPENDENT [complications]; RISK FACTORS; ENVIRONMENTAL RISKS; ISLETS OF LANGERHANS; AUTOANTIBODIES; IgG.

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