Resumo

CALDERIN BOUZA, Raúl Orlando et al. Insulin-resistance and non-alcoholic fatty liver, is there a cause-effect relationship between both conditions?. Rev Cubana Endocrinol [online]. 2009, vol.20, n.1, pp. 0-0. ISSN 1561-2953.

Insulin resistance and the insulin resistance syndrome are the more significant main cause in pathogeny of non-alcoholic fatty liver, together with obesity and type 2 diabetes mellitus. Insulin resistance may be the cause and the consequence of hepatic disease. Prevalence of non-alcoholic fatty liver documented in papers performed in developing countries is at follow: from a 20 % to 23 %, increase in patients presenting with persistent high level of transaminase, in which it is possible to observe a prevalence between 21 % and 63 %, and prevalence of steatohepatitis fluctuates between 2 % and 3 % of population. We must to mark that this prevalence is increasing together with the prevalence increase of insulin resistance syndrome, obesity, and type 2 diabetes mellitus. The non-alcohol fatty liver is the more frequent cause of a persistent high level of transaminase, of chronic liver disease, and of idiopathic liver cirrhosis. An age similar or higher than 40 years, presence of insulin resistance, insulin resistance syndrome, obesity, and type 2 diabetes mellitus darken the prognosis of patients presenting with non-alcoholic fatty liver, so the presence of above mentioned factors is considered as a poor prognosis factors in patient presenting non-alcoholic fatty liver.

Palavras-chave : Insulin resistance syndrome (IRS); insulin resistance (IR); non-alcoholic fatty liver (NAFL); liver cirrhosis (LC); prediabetes,and type 2 diabetes mellitus (2 DM).

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