Resumo

CAMPO DIAZ, Mirta Caridad; FORTUN PRIETO, Adalberto; FORTUN CAMPO, Adalberto  e  HERNANDEZ GONZALEZ, Jorge Luis. Pathophysiology of the vaso-occlusion in the sickle cell anemia. Rev Ciencias Médicas [online]. 2009, vol.13, n.1, pp. 80-89. ISSN 1561-3194.

The vaso-occlusion in the sickle cell anemia is only characteristic in the haemolytic anemias. The idea that the falciform erythrocyte induces the vaso-occlusive process has been abolished and without doubt the event is produced by the adhesion of the low density deformed erythrocytes ( stress reticulocytes ) to the active vascular endothelium in post-capillary venule participating in the process molecules of cellular adhesion ( erythrocytic and vascular) as well as a group of plasma factors; the external phosphatidilserine , the thrombine action , the expression of tissue factor associated to the disorders of the cationic transportation mechanism as well as the aggregates (band 3) are crucial elements in the pathophysiological explanation of vaso-occlusion and its relation to different therapeutic options.

Palavras-chave : Vaso-occlusion; sickle cell anemia; cellular adhesion molecules; band 3 molecule.

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