Resumo

ALONSO REMEDIOS, Alaín et al. Evolution of Immunological Thinking. Medisur [online]. 2016, vol.14, n.2, pp. 204-212. ISSN 1727-897X.

At present, the mechanisms involved in the "decision" of the immune system to promote an essentially effector response or a tolerant response are not fully known. Throughout history, immunological thinking has changed as the available technologies have led to a better understanding of the immune system. For these reasons, the present literature review was conducted to summarize the changes in immunological thinking regarding the fundamental problem of immunology. The concept of horror autotoxicus proposed by Erlich and the meaning of the clonal selection theory for understanding central tolerance were discussed. The two-signal model, Jerne’s contributions and his immune network theory were also addressed. Finally, the danger model and the theory of dominant tolerance were analyzed. The contributions of each theory to understanding how the immune system works were included.

Palavras-chave : thinking; immune system; immune tolerance; systems theory.

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