Resumo

HERNANDEZ FERNANDEZ, Rolando A. Covalent Modifications of Proteins. A qualitative higher level of molecular information. Rev haban cienc méd [online]. 2014, vol.13, n.1, pp. 20-35. ISSN 1729-519X.

Introduction: Molecular information is an essential property of biomacromolecules, especially proteins and nucleic acids. This property allows carrying out specific functions. It derives from variability of macromolecules components. Objetive: To prove that covalent modification of proteins represents a new and higher level of molecular information. Method: Papers published during the last five years in national and international journals were analyzed. These articles are available in HINARI, PubMed, and Perii databases and were localized through www.infomed.sld.cu. Main text: First, the mechanism and features of covalent modifications of protein are presented. Next, the principal effects on protein functions and properties are analyzed. Conclusions: We conclude that covalent modification of proteins represents a new and higher level of molecular information.

Palavras-chave : Covalent modification of protein; molecular information; protein interactions; protein turn over.

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