Resumo

ILLNAIT FERRER, José; FERNANDEZ TRAVIESO, Julio César; REYES NUNEZ, Yenney  e  DUQUESNE CHAVEZ, Alicia de la Caridad. Dementia post ictus: Is policosanol a prevention therapy?. Rev. CENIC Cienc. Biol [online]. 2020, vol.51, n.3, pp. 264-271.  Epub 01-Dez-2020. ISSN 2221-2450.

Stroke is a global health problem related to various risk factors. Although its frequency is increasing with age, it can also appear in young people. The sequelae observed, after the event, include the presence of motor and cognitive disabling effects, including appearance of dementia, Alzheimer disease and, conditioning the recurrence of stroke episodes, all together constituting a serious socioeconomic problem. Taking into account, on one side, the relationship between lipid metabolism disorders, atherosclerosis, the age of onset of stroke and the development of cognitive decline after the event and on the other, that policosanol, a drug of natural origin, has demonstrated efficacy in the treatment of dyslipidemia (a risk factor commonly present in patients suffering a stroke), as well as on their motor and functional recovery, without showing evidences of cognitive decline during a long period of time after occurring the event, then this paper is aimed to assess a putative role of policosanol in preventing cognitive decline or at least decrease the prevalence of its appearing in such patients. A brief analysis on the molecular basis that would support this hypothesis, is done and is concluded that conducting of appropriates clinical assays is needed to prove the presented hypothesis.

Palavras-chave : Dementia; Policosanol; Stroke; Alzheimer Disease; Central Nervous System.

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