Resumo

GUTIERREZ MARTINEZ, Ariadne et al. Acute toxicology of sacha inchi oil in sprague dawley rats. Rev. CENIC Cienc. Biol [online]. 2021, vol.52, n.1, pp. 50-58.  Epub 01-Abr-2021. ISSN 2221-2450.

Sacha inchi oil has great nutritional value due to its high content of polyunsaturated fatty acids and vitamin E. The main fatty acids present in this oil are α-linolenic and linoleic, very important for the prevention of coronary heart disease and hypertension, showing a hypocholesterolemic effect. In our country the plant has been cultivated and this oil has been obtained. However, until now preclinical toxicological studies evaluating the toxicity of oil of Cuban origin have not been carried out, so the objective of the work was to determine oral toxicity by single doses of Sacha inchi oil in Sprague Dawley rats using the acute toxic class method. The treated animals received a single dose of 2000 mg/kg of body weight of Sacha inchi oil, then they were observed at different intervals during the first 24 hours and daily for the remaining days. Body weight was controlled at the beginning, at seven days and at the end of the experience. Food consumption was recorded daily. After 14 days of the administration, the necropsy of all the animals was performed, the macroscopic study revealed that no animal presented lesions in the cavities and organs examined. There were no deaths during the experience and no significant differences were found in body weights and food consumption between treated and control animals. The oil of Sacha inchi presents a low intrinsic toxicity, showing a toxicity by single oral doses higher than 2000 mg/kg of body weight, dose at which no indicative signs of toxicity are evidenced, so that its toxicity can be declared as not classifiable according to the method evaluated.

Palavras-chave : Sacha inchi oil; polyunsaturated fatty acids; acute toxic class; rats; toxicity.

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