Resumo

OYARZABAL YERA, Ambar; PEREZ GUERRA, Yohani; JIMENEZ DESPAIGNE, Sonia  e  MOLINA CUEVAS, Vivian. Effects of D-005, lipid extract of the fruit of Acrocomia Crispa, on oxidative stress induced by carbon tetrachloride in rats. Rev. CENIC Cienc. Biol [online]. 2021, vol.52, n.2, pp. 137-145.  Epub 01-Ago-2021. ISSN 2221-2450.

Oxidative stress is produced by the imbalance between the substances or factors pro-oxidant and the antioxidant defense mechanisms, which in turn plays an important role in the development and progression of various pathologies. D-005, lipid extract from the fruits of Acrocomia crispa contains a reproducible mixture of fatty acids, such as: oleic, palmitic, lauric, myristic, palmitoleic, caprylic, capric, and stearic that have antioxidant properties. The objective of this work is to evaluate the effect of D-005 administered as single oral doses on the increase in indicators of oxidative stress induced by carbon tetrachloride (CCl4) in rats. The animals were randomly distributed into seven groups: a negative control without damage and six groups to which CCl4 was administered (intraperitoneal): a positive control treated with vehicle, four with D-005 (5-100 mg/kg), and one with grape seed extract (ESU) (250 mg/kg). The animals in the positive control group (with CCl4) reached significantly higher values ​​of malondialdehyde-marker of lipid peroxidation-, sulfhydryl groups-marker of protein oxidation- and serum transaminases-marker of liver damage- with respect to the animals of the negative control group (without damage). D-005 and ESU markedly and significantly prevented this increase. In conclusion, D-005 administered as single oral doses of 5, 25, 50, and 100 mg/kg inhibits lipid peroxidation and protein oxidation, as well as CCl4-induced liver damage.

Palavras-chave : D-005; lipid peroxidation; protein oxidation; antioxidant.

        · resumo em Espanhol     · texto em Espanhol     · Espanhol ( pdf )