Resumo

GUTIERREZ MARTINEZ, Ariadne et al. ORAL SINGLE DOSE TOXICITY OF THE SACHA INCHI OIL IN NMRI MICE. Rev. CENIC Cienc. Biol [online]. 2023, vol.54, pp. 16-22.  Epub 19-Out-2023. ISSN 2221-2450.

Sacha inchi is a plant native to the Peruvian Amazon. The oil obtained from its seeds contains high levels of alpha-linolenic acid and linoleic acid, which may provide protective effects against inflammation, cardiovascular disease, and cancer. In Cuba, the plant has been cultivated and the oil has been obtained, so it is important to carry out preclinical studies to evaluate its toxicity. The objective of this work was to determine the toxic effects of Sacha inchi oil, after a single oral administration to NMRI mice of both sexes. The dose administered to the animals was 2000 mg/kg of body weight, then they were observed at different intervals during the first 24 hours and daily for up to 14 days. Body weight was recorded at the beginning, after seven days and at the end of the experience, and food consumption was controlled throughout the experience. There were no deaths or signs indicative of toxicity in any animal. No macroscopic findings were observed during necropsy. In the analysis of body weight and food consumption there were no significant differences between the treated groups and the controls. The administration of single oral doses of Sacha inchi oil to NMRI mice did not show signs indicative of toxicity in either sex, showing an acute oral toxicity greater than 2000 mg/kg of body weight, so according to the method of the acute toxicity classes is not classifiable.

Palavras-chave : Sacha inchi oil; oral administration; mice; acute toxicity.

        · resumo em Espanhol     · texto em Espanhol     · Espanhol ( pdf )