Resumo

PINOL JIMENEZ, Felipe Neri; CAPO DE PAZ, Virginia; GRA ORAMAS, Bienvenido  e  PIERA ROCILLO, Olga María. COVID-19 and bile acids: new perspectives to consider. Anales de la ACC [online]. 2021, vol.11, n.2  Epub 01-Ago-2021. ISSN 2304-0106.

The lack of control of bile acids, signaling molecules with biological and pleotropic actions associated with the intestinal microbiota, the immune system and energy, lipid, glycemic and cholesterol metabolisms, amplifies the inflammatory response from the hepato-intestinal system to other organs involved with multiple failure and death. To describe their biomolecular evidence as possible metabolomic agents associated with complications of COVID-19, a systematic and critical review of what was published between 2000 and 2020 was carried out on their actions in supraphysiological conditions. These could constitute the theoretical basis that infer the damage of the cholangiolar epithelium by SARS-CoV-2, which favors the toxic action of bile acids, and allows the hypothesis of considering them as constituents of an axis that transverse this inflammatory process, as active participants in each of its stages, therefore, prognostic agents of this disease. Clinical studies are recommended for confirmation.

Palavras-chave : colesterol; ácidos biliares; COVID-19; cholesterol; bile acids; COVID-19.

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