Introduction:

HER2 overexpression in mammary carcinoma is associated to a higher biological activity of the tumor and to an unfavorable prognosis.

Objective:

to determine the incidence of pure overexpression of HER2/neu oncogene in mammary carcinomas in “Celestino Hernández” Hospital from Villa Clara Province and its relationship with other variables of prognostic value.

Methods:

descriptive, retrospective study was carried out at the “Celestino Hernández” Hospital between January 2017 and June 2019. It was included 293 women with diagnosis of infiltrating breast carcinoma, the biopsies were subjected to immunohistochemical study to determine the incidence of HER2 oncogene overexpression and its relationship with other variables of prognostic value.

Results:

22 cases (7.5%) with exclusive overexpression of the HER2/neu oncogene were found in the series. Of the patients with carcinomas with HER2 overexpression, 17 (77.3%) were older than 50 years, 20 (90.9%) had tumor size greater than 2 centimeters and 21 (95.45%) were associated with the non-special histological type (ductal carcinoma) of mammary carcinoma. The relationship between HER2/neu oncogene overexpression and moderately and poorly differentiated histological forms of mammary carcinoma stands out. The proliferation index determined by Ki67 was greater than 30% in 17 patients (77.27%).

Conclusion:

postmenopausal age, non-special histological type, high histological grade, high Ki67 indices and tumor size greater than two centimeters are frequently associated with HER2 overexpression in mammary carcinomas.

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