Resumo

TAMARGO SANTOS, Beatriz et al. Diseño y evaluación de la formulación de tabletas de pimozida 1 y 4 mg. Rev Cubana Farm [online]. 1998, vol.32, n.1, pp. 21-27. ISSN 1561-2988.

Different formulations of Pimozide 1 and 4 mg tablets designed to obtain a formulation that meets the parameters established by the United States Pharmacopeia XXII for controlling the quality of the finished product, as well as the necessary requirement for its coating, were studied. Among these formulations, the so-called PP fulfilled the established quality parameters before and after coating. The results obtained in the shelf life study of the coated tablets made at semiindustrial scale showen that even one year after their making they meet the specifications established by the Pharmacopeia, which supports the feasibility for their scale-up at industrial level.

Palavras-chave : CHEMISTRY, PHARMACEUTICAL [methods]; PIMOZIDE [analysis]; TABLETS, ENTERIC-COATED [analysis]; POWDERS [analysis]; DRUG QUALITY; DRUG EVALUATION; DRUG DESIGN.