Resumo

VAZQUEZ VIGOA, Alfredo; CRUZ ALVAREZ, Nélida María; VAZQUEZ CRUZ, Alfredo  e  MILIAN PEREZ, Anayanci. Inhibidores de la enzima de conversión de la angiotensina en el tratamiento de la hipertensión arterial. Rev Cubana Farm [online]. 1998, vol.32, n.3, pp. 204-210. ISSN 1561-2988.

An updated review of the function of angiotensin-converting enzyme inhibitors (ACEI) in the treatment of hypertensive patient is set forth. The mechanism of the action of such drugs, based on the blocking of II angiotension generation and the increase of vasodilatador peptides (bradichinin), and their effects on both the circulating renin- -angiotensin system and the hystic renin-angiotensin system are explained. Their usefulness for treating hypertensive diabetic patient is underline since they invease sensitivity to insuline and prevent diabetic nephropathy. The impact of ACEI on regression of left ventricular hypertrophy and their importance in ischemic heart disease are discussed. It is concluded that ACEI are an effective alternative for hypertensive patient treatment because they help to normalize blood presure in 60 % of cases.

Palavras-chave : ANGIOTENSIN-CONVERTING ENZYME INHIBITORS [therapeutic use]; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS [pharmacology]; HYPERTENSION [drug therapy].

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