Resumo

RUIBAL BRUNET, Ignacio Juan et al. Inactivacion de virus ADN envueltos en la producción de hemoderivados (Albúmina e Inmunoglobulinas). Rev Cubana Farm [online]. 1999, vol.33, n.2, pp. 89-97. ISSN 1561-2988.

Inactivation of human herpes simplex virus I asa model of enveloped DNA virus was studied in the stages of production of intramuscular/ intravenous inmunoglobulins and human albumin, in the phases of alcohol fractionation for obtaining these products, and in the methods of removal and/or inactivation implemented in manufacture, pasteurization and ion - exchange chromatography. The virus was quantified by cytophatic effects. The cumulative reduction values reported in this paper proved that the use of alcohol fractionation in Cuba, as a variant of Cohn - Oncley method, combined with removal/inactivation procedures resulted in enveloped DNA virus inactivation assuring high biological safety for albumin and immunoglobulins for their use in human beings.

Palavras-chave : DNA, VIRAL; HERPES VIRUS 1, HUMAN; SERUM ALBU-MIN, IMMUNOGLOBULINS; DRUG COMPOUNDINGS.

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