SciELO - Scientific Electronic Library Online

 
vol.35 número1Evaluación comparativa de la liberación in vitro de Metildopa de producción nacional contra Aldomet®Comportamiento de la pendiente en el ensayo de linealidad del Rapigluco-Test índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Artigo

Indicadores

  • Não possue artigos citadosCitado por SciELO

Links relacionados

  • Não possue artigos similaresSimilares em SciELO

Compartilhar


Revista Cubana de Farmacia

versão On-line ISSN 1561-2988

Resumo

MARTINEZ MIRANDA, Lisette; LARA CASTRO, Maricela  e  TORRES GARCIA, Matilde. Estabilidad de tabletas de Rifampicina 300 mg. Rev Cubana Farm [online]. 2001, vol.35, n.1, pp. 18-22. ISSN 1561-2988.

The stability study of rifampicin 300 mg was conducted. An analytical method developed and validated by high pressure liquid chromatography in reverse phase and ultraviolet detection was used for the quantification of the actives principle. The stability study of the tablets was conducted by the method of useful life and the accelerated method under isothermic conditions. There was no significant variation of the concentration during the time of study and, thus, the chemical and thermal stability of the active principle was proved. A period of 2 years was proposed as expiration date. A relative humidity of 75, 84 and 92% influenced on the stability of the formulation in the analyzed period.

Palavras-chave : RIFAMPIN [pharmacokinetics]; DRUG STABILITY [methods]; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG QUALITY; CHEMISTRY, PHARMACEUTICAL [methods]; TECHNOLOGY, PHARMACEUTICAL; TABLETS [analysis].

        · resumo em Espanhol     · texto em Espanhol     · Espanhol ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License