Resumo

SANTANA ROMERO, Jorge Luis et al. Biodistribución y farmacocinética de Taninos de Pinus caribaea Morelet y Casuarina equisetifolia en ratones. Rev Cubana Farm [online]. 2002, vol.36, n.2, pp. 112-120. ISSN 1561-2988.

Biodistribution and pharmacokinetics of radioisotope-labeled and purified condensed tannins from Pinus caribaea Morelet var caribaea and Casuarina equisetifolia barks were studied after they were orally and intravenously administered to mice which served as biomodels. The studied tannins, known as strong antioxidants and protein complex ligands, showed a rapid biodistribution into several organs and tissues. Accumulation of these substances in the stomach and intestines was significant. Tannins from both species described a biodistribution that adapted to a biocompartimental model of distribution. Pharmacokinetic parameters such as mean residence time, total clearance, area under the curve, bioavailability and the moment when the maximum incorporation occurs were estimated from the blood clearance curves.

Palavras-chave : MODELS, BIOLOGICAL; MICE; TANNINS [pharmacology]; TANNINS [pharmacokinetics]; PLANTS, MEDICINAL.

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