Resumo

GONZALEZ ESCOBAR, Raimara. Modelos experimentales para la evaluación de la acción cicatrizante de medicamentos. Rev Cubana Farm [online]. 2002, vol.36, n.3, pp. 189-196. ISSN 1561-2988.

The attempts of the organism to repair injuries induced by local aggressions begin very early in the inflammation process and conclude finally with the reparation and substitution of those cells damaged by sound cells. The healing process of a skin wound involves the complex interaction of many types of cells and a sequence of sneaky and closely related processes take place. There are various pharmacological experimental models allowing to evaluate the healing action of an active principle and to go deep into the specific healing events. Details are given in this paper about the following models: model of injury induced by burn in guinea pigs, model of 6 aseptic wounds in pigs, promotion of healing by second intention in rats and a model to predict the distribution of a drug topically applied in wounds. These assays make possible the study of multiple histological, biochemical, cellular and clinical elements, which are characteristic of the healing process.

Palavras-chave : WOUND HEALING; CLINICAL TRIALS [methods]; ANIMALS, LABORATORY; PHARMACEUTICAL PREPARATIONS.

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